I made this lengthy write up, but then I felt silly because it used a lot of limited research to try to suggest Cetirizine/Levocetirizine as a potential defense against ARDS. I actually thought it would make an interesting research proposal (if it is please let me know, want to be a part), given all the other hail marries that are happening, but then I realized I don’t even know how to make a research proposal because I am still on my journey to finishing medical school.
I guess in short (the much shorter version) this was my rationale.
EDITED TO INCLUDE REFERENCES
From a pathophysiological perspective, increased capillary permeability is a major contributing factor to ARDS. In COVID-19, infection from the SARS-CoV-2 seems to produce diffuse and comprehensive cellular damage throughout both lungs.1 Subsequent inflammatory processes become the key in the pathogenesis of ARDS. This diffuse damage releases